What is Induced fit hypothesis
Induced fit hypothesis :
It is proposed by the Daniel Koshland in 1959 Enzyme module are in inactive form to become active; they must undergo a slight change in the structure to become more specific to accommodate the substrate.
The active site can slightly modify as the substrate interacts with enzymes.
according to this model active site of enzyme is not rigid or preshaped but it is static in nature as soon as substrate come contact with enzyme active site of enzyme undergo conformation changes and reaction is proceed.
induced fit model has sufficient experimental evidences from x-ray diffraction studies
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